A Cohort Of Adult Egyptian Patients With Acute Myeloid...

The clinical relevance and prognostic significance of ABCG2 gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia Abstract Purpose ; Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder, with several novel prognostic factors including changes in levels of gene expression. Limited number of clinical studies are available about the role of multidrug transporter adenosine triphosphate–binding cassette protein (ABCG2) gene expression in adult AML. Methods; In this study we measured ABCG2 mRNA expression by quantitative real time RT-PCR in 50 de novo adult AML patients and 20 healthy normal controls. We evaluated the of expression in relation to other clinical and prognostic factors, response to treatment and disease free survival in AML patients to investigate their possible association with clinical outcomes. ABCG2 mRNA was over expressed in AML patients than in control. Results; There was a positive correlation between ABCG2 gene expression level and the percent of CD34expression (p= 0.016, r= 0.330). There was no statistically significant relation between ABCG2 mRNA expre ssion level and response to induction treatment as well as disease free survival of the studied group of patients. Conclusion; ABCG2 m-RNA is over expressed in AML ,but it did not affect the prognosis of the patients. The biology of ABCG2 expression and function in AML is more complex and needs more standardized clinical studies. Key words; ABCG2,

Using Renewable Energy Systems ( Ac ) - 2416 Words

Summary: At present, most distributed renewable energy systems produce direct current (DC) electricity which is then inverted to alternating current (AC) and fed into the electric grid. Simultaneously, many modern building loads and storage systems use rectifiers to convert AC grid electricity to DC for use at the load or battery. Onsite use of renewable energy production therefore requires two energy conversions: DC/AC at the point of generation and AC/DC at the load. The Bosch DC Building Scale Microgrid Platform (DCBMP) offers significant benefits relative to conventional AC grid systems by distributing as much solar power as possible to DC loads/storage, and then inverting only the excess power to AC for AC loads and export to the grid. The DCBMP maximizes the utilization of solar energy on-site, smooths the volatility of the PV output, increases the load and storage efficiencies and minimizes dependence on grid-based electricity. The proposal incorporates long-life (20-25 year s), commercially ready technology, increasing energy efficiency and improving energy security. These features are provided at a low up-front investment when compared to conventional AC-based systems, enabling a levelized cost of electricity (LCOE) less than $0.14/kWh by 2020 for behind-the-meter PV and storage systems and a lower total cost of ownership for the DC loads and DC resources as compared to other approaches, while providing export power to the utility grid through smart inverterShow MoreRelatedUsing Matpower For Wholesale Power Management1518 Words   |  7 Pages Using MATPOWER for Wholesale Power Management Faizul Haque M.E (Eng MGMT) ENN590 – Project Submitted in partial fulfilment of the requirements for the degree of Master of Engineering (Coursework) Science and Engineering Faculty Queensland University of Technology October 2015 Acknowledgements I wish to express my gratitude and appreciation to my Project Supervisor Dr Yateendra Mishra, Course Co-ordinator Dr Dhammika Jayalath and Mechanical Co-ordianator Dr Wijitha Senaeera for theirRead MoreAlternative Energy: Solar Energy1323 Words   |  5 PagesIn the world today, alternative energy source which is an alternative to fossil fuel and nuclear energy is becoming more and more of a necessity. 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Interview with a Counselee Free Essays

This interview was conducted one month after the counseling took place. The counselee was an average high school student who attempted to take suicide by slashing her wrist and cutting her tongue. The counselee informed the author of this paper that she made a suicide attempt due to feelings of abandonment by her family and friends. We will write a custom essay sample on Interview with a Counselee or any similar topic only for you Order Now At present, the student is still undergoing follow-up sessions with the school counselor, and being observed by her class adviser. During the interview, the student showed some mannerisms of biting her fingers, and narrowing her eyes. She and the author (interviewer) sat in front of each other in a small counseling room. 1. When asked about her thoughts and feelings as she prepared for the counseling experience, the student said that she felt a little nervous that the counselor would get mad at her for attempting suicide. She did not want to open up at first because the counselor was unknown to her. Although she often saw the counselor in the school whenever she passed by the counseling room and during the orientation for freshmen, she had not come as close to the counselor as that time when she had counseling. Due to unfamiliarity with the counselor, she somehow felt that she could not trust her, and that the counselor would relay her secrets to other people. 2. The counselee also expressed that when she came inside the counseling room, the counselor smiled at her at once, and asked her to sit. The first words that the counselor uttered were, â€Å"How are you? † When the counselor spoke this, the student said she felt appeased that the counselor was not mad at her. She sensed then that the counselor was concerned about her. During the session, the counselor said that she would value whatever the student would share to her, and her feelings are very precious. She also told the student that everything they would talk about would be confidential, and as long as the counselee promises never to do the attempt again, the counselor would not inform her parents of what the student shared to her. Because of this, the student said she felt comfortable with the counselor and could not help but to express what she felt and thought that day. In assurance, the counselor said that she could be of help to the counselee if the counselee would allow her to help. In this particular counseling situation, we may note that the counselor was successful in building up rapport between her and the counselee. She did this by expressing that she values the feelings of the counselee (Wexler, as cited in Lambie, 2004 ), and the counselee could trust her with secrets. 3. As regards the obstacles that hindered the counselee from sharing her experience with the counselor, the counselee commented that due to the friendly approach and concern of the counselor, she felt at ease with her. 4. When asked what she learned about the helping/counseling process after undergoing it, the student said that she was very glad that they have a service like this in school and through this program she realized a couple of things. First, she realized that some people are concerned about her and she could find a friend among them, such as the counselor and other counselors as well. She also stated that she felt lucky that her school has a friendly and compassionate counselor who would listen to her, without condemning what she did. She also appreciated the fact that the counselor was not grading her for how she performed during the counseling session, and she did not have to be conscious of what she would tell the counselor. In other words, the process made her express her real self and provided her someone whom she felt was concerned. 5. As we can see, the counseling process that took place was of great help to the student. Through the school counseling program, students like the interviewee in this report are given the attention they need. Just like any counseling process, it is very important for every counselor to listen attentively, offer advice when needed, and make the counselee feel comfortable. In the case of the student, we may say that a lot of students nowadays have a different view of counseling unless they have undergone one. The misconceptions expressed by the counselee before the session include imagining the counselor getting mad at her, or relaying her secrets to her parents. These are the same examples of how some students view counseling. However, these misconceptions are proven wrong once they encounter the real counseling experience. Reference Lambie, Glenn. Motivational enhancement therapy: A tool for professional school counselors working with adolescents. Professional School Counseling. Retrieved February 1, 2008, from http://findarticles. com/p/articles/mi_m0KOC/is_4_7/ai_n6033401 How to cite Interview with a Counselee, Papers